Drug interactions
Empagliflozin-linagliptin + Lithium
Severity: Moderate
Empagliflozin-linagliptin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors such as empagliflozin may lower serum lithium concentrations. Reduced lithium levels could lead to loss of mood stabilization and relapse in patients with bipolar disorder.
What this interaction means in plain words
Empagliflozin-linagliptin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
The mechanism is not well established; altered renal sodium and lithium handling is suspected.
What to do
Measure serum lithium more often after starting, stopping or changing the dose of empagliflozin. Adjust the lithium dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Lithium?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors such as empagliflozin may lower serum lithium concentrations. Reduced lithium levels could lead to loss of mood stabilization and relapse in patients with bipolar disorder.
How serious is the interaction between Empagliflozin-linagliptin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum lithium more often after starting, stopping or changing the dose of empagliflozin. Adjust the lithium dose according to levels and clinical response.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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