Drug interactions
Empagliflozin-linagliptin + Phenobarbital
Severity: Moderate
Empagliflozin-linagliptin and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an enzyme inducer that can lower linagliptin exposure and weaken its glucose-lowering effect. The effect develops over days to weeks and persists after phenobarbital is stopped.
What this interaction means in plain words
Empagliflozin-linagliptin and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and P-gp by phenobarbital increases linagliptin elimination.
What to do
Monitor blood glucose and HbA1c and consider an alternative antidiabetic agent if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Frequently asked questions
Can I take Empagliflozin-linagliptin with Phenobarbital?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is an enzyme inducer that can lower linagliptin exposure and weaken its glucose-lowering effect. The effect develops over days to weeks and persists after phenobarbital is stopped.
How serious is the interaction between Empagliflozin-linagliptin and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and consider an alternative antidiabetic agent if control is inadequate.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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