Drug interactions
Enalapril + Exenatide
Severity: Minor
Enalapril and Exenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been associated with a greater glucose-lowering effect in patients on antidiabetic therapy. When added to exenatide, this may slightly increase the chance of low blood glucose, especially if combined with a sulfonylurea or insulin.
What this interaction means in plain words
Enalapril and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Exenatide belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake, adding to the glucose-lowering action of exenatide.
What to do
Monitor blood glucose when starting or stopping the ACE inhibitor, particularly during the first weeks. Reduce the dose of any co-prescribed sulfonylurea or insulin if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Exenatide?
MediHelp rates the interaction as minor. Enalapril and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and have been associated with a greater glucose-lowering effect in patients on antidiabetic therapy. When added to exenatide, this may slightly increase the chance of low blood glucose, especially if combined with a sulfonylurea or insulin.
How serious is the interaction between Enalapril and Exenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the ACE inhibitor, particularly during the first weeks. Reduce the dose of any co-prescribed sulfonylurea or insulin if hypoglycemia occurs.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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