Drug interactions
Enalapril + Glecaprevir / pibrentasvir
Severity: Minor
Enalapril and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit hepatic uptake transporters and may raise exposure to drugs that rely on them. Enalapril and its active metabolite enalaprilat may therefore be present at higher concentrations, with a possible increase in hypotension or renal and potassium effects. The change is expected to be modest.
What this interaction means in plain words
Enalapril and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake by glecaprevir/pibrentasvir may increase enalapril exposure.
What to do
No routine dose change is needed; monitor blood pressure, renal function and serum potassium when starting or stopping the antiviral regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Enalapril and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit hepatic uptake transporters and may raise exposure to drugs that rely on them. Enalapril and its active metabolite enalaprilat may therefore be present at higher concentrations, with a possible increase in hypotension or renal and potassium effects. The change is expected to be modest.
How serious is the interaction between Enalapril and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood pressure, renal function and serum potassium when starting or stopping the antiviral regimen.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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