Drug interactions
Enalapril + Glimepiride-pioglitazone
Severity: Minor
Enalapril and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally increase the hypoglycemic effect of sulfonylureas such as glimepiride. Hypoglycemia is uncommon but reported, especially early in therapy.
What this interaction means in plain words
Enalapril and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake, adding to the sulfonylurea effect.
What to do
Monitor blood glucose when starting an ACE inhibitor and adjust the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Enalapril and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and occasionally increase the hypoglycemic effect of sulfonylureas such as glimepiride. Hypoglycemia is uncommon but reported, especially early in therapy.
How serious is the interaction between Enalapril and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting an ACE inhibitor and adjust the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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