Drug interactions
Enalapril + Gold sodium thiomalate
Severity: Moderate
Enalapril and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold given with ACE inhibitors has been associated with nitritoid reactions, consisting of facial flushing, nausea, vomiting and low blood pressure. These reactions are uncommon but can be distressing and may cause symptomatic hypotension.
What this interaction means in plain words
Enalapril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; vasodilatory effects of gold may be potentiated by ACE inhibition.
What to do
Observe the patient after each gold injection and warn them about flushing and dizziness. If reactions recur, consider an alternative antihypertensive or disease-modifying therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Enalapril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold given with ACE inhibitors has been associated with nitritoid reactions, consisting of facial flushing, nausea, vomiting and low blood pressure. These reactions are uncommon but can be distressing and may cause symptomatic hypotension.
How serious is the interaction between Enalapril and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient after each gold injection and warn them about flushing and dizziness. If reactions recur, consider an alternative antihypertensive or disease-modifying therapy.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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