Drug interactions
Enalapril + Heparin
Severity: Moderate
Enalapril and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion and raise serum potassium. With enalapril, which also lowers aldosterone, hyperkalemia is more likely, especially in patients with renal impairment or diabetes.
What this interaction means in plain words
Enalapril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Additive aldosterone suppression from heparin and ACE inhibition, resulting in potassium retention.
What to do
Monitor serum potassium and renal function if heparin is given for more than a few days. Treat hyperkalemia and review other potassium-raising drugs if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Enalapril with Heparin?
MediHelp rates the interaction as moderate. Enalapril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion and raise serum potassium. With enalapril, which also lowers aldosterone, hyperkalemia is more likely, especially in patients with renal impairment or diabetes.
How serious is the interaction between Enalapril and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if heparin is given for more than a few days. Treat hyperkalemia and review other potassium-raising drugs if it occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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