Drug interactions
Enalapril + Insulin inhaled
Severity: Moderate
Enalapril and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enalapril may increase insulin sensitivity and strengthen the glucose-lowering effect of inhaled insulin. This increases the risk of hypoglycemia, especially at the start of ACE inhibitor therapy.
What this interaction means in plain words
Enalapril and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition improves insulin sensitivity, producing additive glucose-lowering effects.
What to do
Check blood glucose more frequently after starting or adjusting enalapril and lower the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Insulin inhaled?
MediHelp rates the interaction as moderate. Enalapril and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enalapril may increase insulin sensitivity and strengthen the glucose-lowering effect of inhaled insulin. This increases the risk of hypoglycemia, especially at the start of ACE inhibitor therapy.
How serious is the interaction between Enalapril and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more frequently after starting or adjusting enalapril and lower the insulin dose if hypoglycemia occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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