Drug interactions
Enalapril + Insulin lispro
Severity: Moderate
Enalapril and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may improve insulin sensitivity and amplify the glucose-lowering effect of insulin lispro. This can result in more frequent hypoglycemia, particularly at the start of ACE inhibitor therapy.
What this interaction means in plain words
Enalapril and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Insulin lispro belongs to Endocrine.
Why it happens
ACE inhibition increases bradykinin and improves peripheral insulin sensitivity, producing an additive glucose-lowering effect.
What to do
Monitor blood glucose more often when enalapril is started or the dose changed. Reduce the insulin lispro dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Insulin lispro
Frequently asked questions
Can I take Enalapril with Insulin lispro?
MediHelp rates the interaction as moderate. Enalapril and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may improve insulin sensitivity and amplify the glucose-lowering effect of insulin lispro. This can result in more frequent hypoglycemia, particularly at the start of ACE inhibitor therapy.
How serious is the interaction between Enalapril and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when enalapril is started or the dose changed. Reduce the insulin lispro dose if hypoglycemia occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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