Drug interactions
Enalapril + Insulin nph
Severity: Moderate
Enalapril and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enalapril can enhance insulin sensitivity and increase the hypoglycemic effect of NPH insulin. Episodes of low blood glucose are more likely when the ACE inhibitor is newly started.
What this interaction means in plain words
Enalapril and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition improves insulin sensitivity, producing additive glucose-lowering effects.
What to do
Monitor blood glucose closely during the first weeks of combined therapy and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Insulin nph?
MediHelp rates the interaction as moderate. Enalapril and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enalapril can enhance insulin sensitivity and increase the hypoglycemic effect of NPH insulin. Episodes of low blood glucose are more likely when the ACE inhibitor is newly started.
How serious is the interaction between Enalapril and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the first weeks of combined therapy and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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