Drug interactions
Enalapril + Meclofenamate
Severity: Moderate
Enalapril and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can blunt enalapril's blood pressure lowering effect and increases the risk of renal function decline. The risk is higher in older adults, in volume depletion and in chronic kidney disease.
What this interaction means in plain words
Enalapril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis reduces renal perfusion and counteracts ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol or the shortest NSAID course in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Meclofenamate?
MediHelp rates the interaction as moderate. Enalapril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can blunt enalapril's blood pressure lowering effect and increases the risk of renal function decline. The risk is higher in older adults, in volume depletion and in chronic kidney disease.
How serious is the interaction between Enalapril and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol or the shortest NSAID course in at-risk patients.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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