Drug interactions
Enalapril + Metformin-sitagliptin
Severity: Moderate
Enalapril and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and glucose lowering, occasionally causing hypoglycemia. Changes in renal function with ACE inhibitors can also increase metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Enalapril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic enhancement of glucose lowering; renal hemodynamic effects can reduce metformin clearance.
What to do
Monitor blood glucose and renal function, particularly after dose changes or during acute illness. Hold metformin if renal function deteriorates significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Enalapril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and glucose lowering, occasionally causing hypoglycemia. Changes in renal function with ACE inhibitors can also increase metformin accumulation and lactic acidosis risk.
How serious is the interaction between Enalapril and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, particularly after dose changes or during acute illness. Hold metformin if renal function deteriorates significantly.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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