Drug interactions
Enalapril + Mipomersen
Severity: Minor
Enalapril and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation. Enalapril rarely causes liver injury, so the combined hepatic risk is small and mostly additive in theory.
What this interaction means in plain words
Enalapril and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Potential additive hepatotoxicity; no established pharmacokinetic interaction.
What to do
Follow the mipomersen liver enzyme monitoring schedule and investigate any rise in transaminases for contributing drugs including enalapril.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Mipomersen?
MediHelp rates the interaction as minor. Enalapril and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation. Enalapril rarely causes liver injury, so the combined hepatic risk is small and mostly additive in theory.
How serious is the interaction between Enalapril and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the mipomersen liver enzyme monitoring schedule and investigate any rise in transaminases for contributing drugs including enalapril.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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