Drug interactions
Enalapril + Nesiritide
Severity: Moderate
Enalapril and Nesiritide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent vasodilator and may add to the blood pressure lowering of enalapril. Symptomatic hypotension is the main concern, particularly in volume-depleted patients.
What this interaction means in plain words
Enalapril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure continuously during nesiritide infusion and reduce or stop the infusion if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Nesiritide?
MediHelp rates the interaction as moderate. Enalapril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent vasodilator and may add to the blood pressure lowering of enalapril. Symptomatic hypotension is the main concern, particularly in volume-depleted patients.
How serious is the interaction between Enalapril and Nesiritide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during nesiritide infusion and reduce or stop the infusion if hypotension occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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