Drug interactions
Enalapril + Olanzapine / samidorphan
Severity: Moderate
Enalapril and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives such as enalapril. This can result in dizziness, syncope and falls, especially early in treatment.
What this interaction means in plain words
Enalapril and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from olanzapine alpha-1 adrenergic antagonism and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting olanzapine. Reduce enalapril dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Enalapril and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives such as enalapril. This can result in dizziness, syncope and falls, especially early in treatment.
How serious is the interaction between Enalapril and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting olanzapine. Reduce enalapril dose if hypotension occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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