Drug interactions
Enalapril + Promazine
Severity: Moderate
Enalapril and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine, a phenothiazine with alpha-adrenergic blocking activity, can cause orthostatic hypotension. With enalapril, blood pressure lowering may be additive, increasing the risk of dizziness and falls.
What this interaction means in plain words
Enalapril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from phenothiazine alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure including orthostatic readings after starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Promazine?
MediHelp rates the interaction as moderate. Enalapril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine, a phenothiazine with alpha-adrenergic blocking activity, can cause orthostatic hypotension. With enalapril, blood pressure lowering may be additive, increasing the risk of dizziness and falls.
How serious is the interaction between Enalapril and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings after starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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