Drug interactions
Enalapril + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Enalapril and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel-preparation solutions can cause fluid loss and electrolyte shifts. In a patient taking enalapril this volume depletion may precipitate acute kidney injury and hypotension, and the potassium content may add to ACE inhibitor-related hyperkalemia.
What this interaction means in plain words
Enalapril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep induced volume depletion and electrolyte disturbance reduce renal perfusion, which is poorly tolerated with ACE inhibition, plus additive potassium load.
What to do
Ensure adequate hydration and consider withholding enalapril on the day of bowel preparation in volume-depleted or renally impaired patients. Check renal function and potassium afterward if symptoms or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril and Sodium sulfate / ?magnesium sulfate / potassium chloride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Enalapril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel-preparation solutions can cause fluid loss and electrolyte shifts. In a patient taking enalapril this volume depletion may precipitate acute kidney injury and hypotension, and the potassium content may add to ACE inhibitor-related hyperkalemia.
How serious is the interaction between Enalapril and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider withholding enalapril on the day of bowel preparation in volume-depleted or renally impaired patients. Check renal function and potassium afterward if symptoms or risk factors are present.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
