Drug interactions
Enalapril + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Enalapril and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel-preparation solutions can cause fluid loss and electrolyte disturbances. With enalapril, dehydration may lead to hypotension and acute kidney injury, and the potassium load may add to hyperkalemia risk.
What this interaction means in plain words
Enalapril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep induced volume depletion lowers renal perfusion, which is poorly tolerated with ACE inhibition, plus a small additive potassium load.
What to do
Ensure adequate hydration and consider holding enalapril on the day of the preparation in high-risk patients such as the elderly or those with renal impairment. Monitor renal function and electrolytes if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Enalapril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel-preparation solutions can cause fluid loss and electrolyte disturbances. With enalapril, dehydration may lead to hypotension and acute kidney injury, and the potassium load may add to hyperkalemia risk.
How serious is the interaction between Enalapril and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider holding enalapril on the day of the preparation in high-risk patients such as the elderly or those with renal impairment. Monitor renal function and electrolytes if symptoms develop.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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