Drug interactions
Enalapril + Sofosbuvir / velpatasvir
Severity: Minor
Enalapril and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP transporters, and enalaprilat formation and hepatic uptake of enalapril may be affected. Any change in exposure is expected to be modest and of limited clinical significance.
What this interaction means in plain words
Enalapril and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibition of OATP1B1/1B3/2B1 may slightly alter enalapril hepatic uptake and disposition.
What to do
No dose change is generally needed; monitor blood pressure when starting or stopping the antiviral combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Enalapril and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits OATP transporters, and enalaprilat formation and hepatic uptake of enalapril may be affected. Any change in exposure is expected to be modest and of limited clinical significance.
How serious is the interaction between Enalapril and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor blood pressure when starting or stopping the antiviral combination.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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