Drug interactions
Enalapril + Synthetic human angiotensin ii
Severity: Moderate
Enalapril and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce conversion of angiotensin I to angiotensin II, so patients on enalapril may respond more strongly to exogenous angiotensin II. This can produce an exaggerated pressor response.
What this interaction means in plain words
Enalapril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition lowers endogenous angiotensin II, increasing sensitivity to the exogenous peptide and its pressor effect.
What to do
Start angiotensin II at the low end of the dosing range and titrate to blood pressure with continuous monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Enalapril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors reduce conversion of angiotensin I to angiotensin II, so patients on enalapril may respond more strongly to exogenous angiotensin II. This can produce an exaggerated pressor response.
How serious is the interaction between Enalapril and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start angiotensin II at the low end of the dosing range and titrate to blood pressure with continuous monitoring.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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