Drug interactions
Enalapril + Xipamide
Severity: Moderate
Enalapril and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and combined use with enalapril lowers blood pressure further. Excessive hypotension can occur, particularly at initiation or in volume- or sodium-depleted patients, with a risk of renal impairment.
What this interaction means in plain words
Enalapril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from diuretic-induced volume depletion and RAAS blockade.
What to do
Monitor blood pressure, renal function and electrolytes after starting the combination. Consider lowering the diuretic dose or starting enalapril at a low dose in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Xipamide?
MediHelp rates the interaction as moderate. Enalapril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and combined use with enalapril lowers blood pressure further. Excessive hypotension can occur, particularly at initiation or in volume- or sodium-depleted patients, with a risk of renal impairment.
How serious is the interaction between Enalapril and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting the combination. Consider lowering the diuretic dose or starting enalapril at a low dose in volume-depleted patients.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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