Drug interactions
Encorafenib + Ethinyl estradiol-norgestimate
Severity: Moderate
Encorafenib and Ethinyl estradiol-norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits BCRP and may modestly increase ethinyl estradiol exposure. Encorafenib may also induce CYP3A4 and reduce contraceptive efficacy, so the net effect on contraception is uncertain.
What this interaction means in plain words
Encorafenib and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
BCRP inhibition by encorafenib may increase ethinyl estradiol exposure, while CYP3A4 induction may decrease it.
What to do
Advise an effective non-hormonal contraceptive method during encorafenib treatment. Monitor for estrogenic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Encorafenib and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits BCRP and may modestly increase ethinyl estradiol exposure. Encorafenib may also induce CYP3A4 and reduce contraceptive efficacy, so the net effect on contraception is uncertain.
How serious is the interaction between Encorafenib and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an effective non-hormonal contraceptive method during encorafenib treatment. Monitor for estrogenic adverse effects.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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