Drug interactions
Encorafenib + Etoposide
Severity: Moderate
Encorafenib and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed effects on CYP3A4, inducing and inhibiting it, so etoposide exposure may rise or fall unpredictably. Either toxicity or reduced antitumor efficacy is possible.
What this interaction means in plain words
Encorafenib and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Etoposide belongs to Oncology.
Why it happens
Encorafenib both induces and inhibits CYP3A4, altering etoposide metabolism in an unpredictable direction.
What to do
Monitor blood counts and clinical response to etoposide. Adjust the etoposide dose according to toxicity or loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Etoposide?
MediHelp rates the interaction as moderate. Encorafenib and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed effects on CYP3A4, inducing and inhibiting it, so etoposide exposure may rise or fall unpredictably. Either toxicity or reduced antitumor efficacy is possible.
How serious is the interaction between Encorafenib and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical response to etoposide. Adjust the etoposide dose according to toxicity or loss of effect.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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