Drug interactions
Encorafenib + Fentanyl
Severity: Moderate
Encorafenib and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed effects on CYP3A4, inhibiting and inducing it, so fentanyl exposure may rise or fall unpredictably. This can lead to either opioid toxicity or inadequate analgesia.
What this interaction means in plain words
Encorafenib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Fentanyl belongs to Musculoskeletal.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering fentanyl metabolism in an unpredictable direction.
What to do
Monitor for both sedation or respiratory depression and loss of analgesia, and titrate fentanyl to effect when encorafenib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Fentanyl?
MediHelp rates the interaction as moderate. Encorafenib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed effects on CYP3A4, inhibiting and inducing it, so fentanyl exposure may rise or fall unpredictably. This can lead to either opioid toxicity or inadequate analgesia.
How serious is the interaction between Encorafenib and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for both sedation or respiratory depression and loss of analgesia, and titrate fentanyl to effect when encorafenib is started or stopped.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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