Drug interactions
Encorafenib + Glibenclamide
Severity: Moderate
Encorafenib and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit OATP1B1, OATP1B3 and BCRP, transporters involved in glyburide disposition. Glyburide levels may increase, raising the risk of hypoglycemia.
What this interaction means in plain words
Encorafenib and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Glibenclamide belongs to Endocrine.
Why it happens
Inhibition of hepatic uptake and efflux transporters (OATP1B1/1B3, BCRP) by encorafenib reduces glyburide clearance.
What to do
Monitor blood glucose closely and consider reducing the glyburide dose during encorafenib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Glibenclamide?
MediHelp rates the interaction as moderate. Encorafenib and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib may inhibit OATP1B1, OATP1B3 and BCRP, transporters involved in glyburide disposition. Glyburide levels may increase, raising the risk of hypoglycemia.
How serious is the interaction between Encorafenib and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the glyburide dose during encorafenib therapy.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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