Drug interactions
Encorafenib + Hydrochlorothiazide-olmesartan
Severity: Minor
Encorafenib and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits the hepatic uptake transporters OATP1B1 and OATP1B3, which handle olmesartan. Olmesartan exposure may therefore rise modestly, with a greater antihypertensive effect or more adverse effects. The magnitude is uncertain and probably small.
What this interaction means in plain words
Encorafenib and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake reduces olmesartan clearance.
What to do
Monitor blood pressure, renal function and potassium during coadministration. Reduce the olmesartan dose if hypotension or other adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Encorafenib and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib inhibits the hepatic uptake transporters OATP1B1 and OATP1B3, which handle olmesartan. Olmesartan exposure may therefore rise modestly, with a greater antihypertensive effect or more adverse effects. The magnitude is uncertain and probably small.
How serious is the interaction between Encorafenib and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium during coadministration. Reduce the olmesartan dose if hypotension or other adverse effects develop.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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