Drug interactions
Encorafenib + Lansoprazole
Severity: Minor
Encorafenib and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so exposure to CYP3A4 substrates can change unpredictably. Lansoprazole is partly metabolized by CYP3A4, so its levels could rise or fall, although the clinical impact is likely small.
What this interaction means in plain words
Encorafenib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Encorafenib exerts mixed inhibition and induction of CYP3A4, altering lansoprazole metabolism.
What to do
No routine dose change is needed; monitor acid-suppression efficacy and adverse effects of lansoprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Lansoprazole?
MediHelp rates the interaction as minor. Encorafenib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib both inhibits and induces CYP3A4, so exposure to CYP3A4 substrates can change unpredictably. Lansoprazole is partly metabolized by CYP3A4, so its levels could rise or fall, although the clinical impact is likely small.
How serious is the interaction between Encorafenib and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor acid-suppression efficacy and adverse effects of lansoprazole.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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