Drug interactions
Encorafenib + Levosalbutamol
Severity: Moderate
Encorafenib and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval in a dose-dependent manner, and levosalbutamol may add to arrhythmic risk through tachycardia and hypokalemia. The risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Encorafenib and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Levosalbutamol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with beta-2 agonist induced hypokalemia as a contributing factor.
What to do
Correct potassium and magnesium before starting and monitor ECG during combined use. Avoid frequent high-dose levosalbutamol where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Levosalbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levosalbutamol
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Levosalbutamol?
MediHelp rates the interaction as moderate. Encorafenib and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can prolong the QT interval in a dose-dependent manner, and levosalbutamol may add to arrhythmic risk through tachycardia and hypokalemia. The risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Encorafenib and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting and monitor ECG during combined use. Avoid frequent high-dose levosalbutamol where alternatives exist.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
