Drug interactions
Encorafenib + Methotrexate
Severity: Moderate
Encorafenib and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, transporters involved in methotrexate disposition. Methotrexate exposure may increase, raising the risk of toxicity.
What this interaction means in plain words
Encorafenib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Inhibition of hepatic uptake and efflux transporters may reduce methotrexate clearance.
What to do
Monitor blood counts and liver and renal function closely. Consider reducing the methotrexate dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Methotrexate?
MediHelp rates the interaction as moderate. Encorafenib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, transporters involved in methotrexate disposition. Methotrexate exposure may increase, raising the risk of toxicity.
How serious is the interaction between Encorafenib and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver and renal function closely. Consider reducing the methotrexate dose if toxicity occurs.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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