Drug interactions
Encorafenib + Olmesartan
Severity: Minor
Encorafenib and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit hepatic uptake transporters OATP1B1 and OATP1B3, which contribute to olmesartan's hepatic disposition. This may raise olmesartan exposure, though the clinical effect is probably modest.
What this interaction means in plain words
Encorafenib and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Olmesartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of olmesartan by encorafenib, which may increase systemic exposure.
What to do
Monitor blood pressure and for signs of excess olmesartan effect such as hypotension or hyperkalemia. Adjust the olmesartan dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Olmesartan?
MediHelp rates the interaction as minor. Encorafenib and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib may inhibit hepatic uptake transporters OATP1B1 and OATP1B3, which contribute to olmesartan's hepatic disposition. This may raise olmesartan exposure, though the clinical effect is probably modest.
How serious is the interaction between Encorafenib and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for signs of excess olmesartan effect such as hypotension or hyperkalemia. Adjust the olmesartan dose if needed.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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