Drug interactions
Encorafenib + Pitavastatin
Severity: Moderate
Encorafenib and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may increase pitavastatin exposure and raise the risk of statin-related myopathy. The effect is predicted from transporter inhibition.
What this interaction means in plain words
Encorafenib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Pitavastatin belongs to Cardiovascular.
Why it happens
Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, reducing hepatic uptake and efflux of pitavastatin.
What to do
Monitor for muscle pain or weakness and consider lowering the pitavastatin dose. Check CK if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Pitavastatin?
MediHelp rates the interaction as moderate. Encorafenib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib may increase pitavastatin exposure and raise the risk of statin-related myopathy. The effect is predicted from transporter inhibition.
How serious is the interaction between Encorafenib and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and consider lowering the pitavastatin dose. Check CK if symptoms arise.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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