Drug interactions
Encorafenib + Rabeprazole
Severity: Minor
Encorafenib and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can both inhibit and induce CYP3A4, but rabeprazole is mainly cleared non-enzymatically. Clinically significant changes in rabeprazole exposure are not expected.
What this interaction means in plain words
Encorafenib and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib may slightly alter the minor oxidative metabolism of rabeprazole.
What to do
No dose adjustment is needed; monitor symptom control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Rabeprazole?
MediHelp rates the interaction as minor. Encorafenib and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib can both inhibit and induce CYP3A4, but rabeprazole is mainly cleared non-enzymatically. Clinically significant changes in rabeprazole exposure are not expected.
How serious is the interaction between Encorafenib and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor symptom control.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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