Drug interactions
Encorafenib + Sildenafil
Severity: Moderate
Encorafenib and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so sildenafil exposure may rise or fall unpredictably. This could cause either increased adverse effects such as hypotension or loss of efficacy.
What this interaction means in plain words
Encorafenib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Sildenafil belongs to Genitourinary.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib alters sildenafil metabolism.
What to do
Monitor response and tolerability when sildenafil is combined with encorafenib, and adjust the sildenafil dose accordingly. Start at a low dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Sildenafil?
MediHelp rates the interaction as moderate. Encorafenib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so sildenafil exposure may rise or fall unpredictably. This could cause either increased adverse effects such as hypotension or loss of efficacy.
How serious is the interaction between Encorafenib and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and tolerability when sildenafil is combined with encorafenib, and adjust the sildenafil dose accordingly. Start at a low dose.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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