Drug interactions
Encorafenib + Telmisartan-amlodipine
Severity: Minor
Encorafenib and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits OATP1B3, and telmisartan is partly taken up by OATP transporters, so telmisartan levels may rise. The clinical importance is uncertain.
What this interaction means in plain words
Encorafenib and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic OATP1B3-mediated uptake of telmisartan.
What to do
Monitor blood pressure, renal function and potassium, and reduce telmisartan dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Encorafenib and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib inhibits OATP1B3, and telmisartan is partly taken up by OATP transporters, so telmisartan levels may rise. The clinical importance is uncertain.
How serious is the interaction between Encorafenib and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, and reduce telmisartan dose if adverse effects appear.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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