Drug interactions
Encorafenib + Telmisartan
Severity: Moderate
Encorafenib and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit hepatic uptake transporters and increase exposure to substrates such as telmisartan. This could enhance telmisartan effects, including hypotension.
What this interaction means in plain words
Encorafenib and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Telmisartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B3-mediated transport of telmisartan.
What to do
Monitor blood pressure and renal function and reduce the telmisartan dose if exaggerated effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Telmisartan?
MediHelp rates the interaction as moderate. Encorafenib and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib may inhibit hepatic uptake transporters and increase exposure to substrates such as telmisartan. This could enhance telmisartan effects, including hypotension.
How serious is the interaction between Encorafenib and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and reduce the telmisartan dose if exaggerated effects appear.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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