Drug interactions
Encorafenib + Tofacitinib
Severity: Moderate
Encorafenib and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed effects on CYP3A4, inhibiting and inducing it, so the net effect on tofacitinib exposure is unpredictable. Either increased toxicity or reduced efficacy may occur.
What this interaction means in plain words
Encorafenib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering tofacitinib metabolism unpredictably.
What to do
Monitor for tofacitinib adverse effects such as infection and cytopenias, and for loss of response. Adjust the dose based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Tofacitinib?
MediHelp rates the interaction as moderate. Encorafenib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed effects on CYP3A4, inhibiting and inducing it, so the net effect on tofacitinib exposure is unpredictable. Either increased toxicity or reduced efficacy may occur.
How serious is the interaction between Encorafenib and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tofacitinib adverse effects such as infection and cytopenias, and for loss of response. Adjust the dose based on clinical response.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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