Drug interactions
Encorafenib + Ulipristal
Severity: Moderate
Encorafenib and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so ulipristal exposure may rise or fall unpredictably. Reduced exposure could lead to emergency contraception failure, while increased exposure could increase adverse effects.
What this interaction means in plain words
Encorafenib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters ulipristal metabolism.
What to do
Prefer a copper IUD as emergency contraception. Encorafenib may also reduce hormonal contraceptive effectiveness, so advise a non-hormonal method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Ulipristal?
MediHelp rates the interaction as moderate. Encorafenib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so ulipristal exposure may rise or fall unpredictably. Reduced exposure could lead to emergency contraception failure, while increased exposure could increase adverse effects.
How serious is the interaction between Encorafenib and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a copper IUD as emergency contraception. Encorafenib may also reduce hormonal contraceptive effectiveness, so advise a non-hormonal method.
What other medicines interact with Encorafenib?
MediHelp also lists interactions of Encorafenib with, for example, Amiodarone, Amisulpride, Amitriptyline. The full list is on the Encorafenib page.
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