Drug interactions
Epinephrine + Epinephrine inhaled
Severity: Moderate
Epinephrine and Epinephrine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using systemic epinephrine together with inhaled epinephrine adds to total epinephrine exposure. This can increase heart rate, blood pressure and arrhythmia risk, mainly when inhaled doses are repeated or high.
What this interaction means in plain words
Epinephrine and Epinephrine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate therapy with additive adrenergic receptor stimulation.
What to do
Avoid unnecessary duplicate use and account for total epinephrine given. Monitor heart rate and blood pressure, especially in cardiac patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Epinephrine inhaled?
MediHelp rates the interaction as moderate. Epinephrine and Epinephrine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using systemic epinephrine together with inhaled epinephrine adds to total epinephrine exposure. This can increase heart rate, blood pressure and arrhythmia risk, mainly when inhaled doses are repeated or high.
How serious is the interaction between Epinephrine and Epinephrine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplicate use and account for total epinephrine given. Monitor heart rate and blood pressure, especially in cardiac patients.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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