Drug interactions
Epinephrine + Ex vivo expanded autologous human corneal epithelial cells containing stem cells
Severity: Major
Epinephrine and Ex vivo expanded autologous human corneal epithelial cells containing stem cells: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine-containing anesthetic preparations contacting the graft site or cells may reduce colony-forming efficiency of the cultured stem cells. This may compromise graft success.
What this interaction means in plain words
Epinephrine and Ex vivo expanded autologous human corneal epithelial cells containing stem cells can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epinephrine belongs to Endocrine; Ex vivo expanded autologous human corneal epithelial cells containing stem cells belongs to Miscellaneous.
Why it happens
Probable cytotoxic effect on cultured cells; mechanism not well established.
What to do
Avoid anesthetics containing epinephrine at the application site. Follow the product labeling on permitted anesthesia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ex vivo expanded autologous human corneal epithelial cells containing stem cells
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Ex vivo expanded autologous human corneal epithelial cells containing stem cells?
MediHelp rates the interaction as major. Epinephrine and Ex vivo expanded autologous human corneal epithelial cells containing stem cells can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Epinephrine-containing anesthetic preparations contacting the graft site or cells may reduce colony-forming efficiency of the cultured stem cells. This may compromise graft success.
How serious is the interaction between Epinephrine and Ex vivo expanded autologous human corneal epithelial cells containing stem cells?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anesthetics containing epinephrine at the application site. Follow the product labeling on permitted anesthesia.
What other medicines interact with Ex vivo expanded autologous human corneal epithelial cells containing stem cells?
MediHelp also lists interactions of Ex vivo expanded autologous human corneal epithelial cells containing stem cells with, for example, Lidocaine. The full list is on the Ex vivo expanded autologous human corneal epithelial cells containing stem cells page.
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