Drug interactions
Epinephrine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Epinephrine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine promotes cellular potassium uptake via beta-2 receptors and may lower serum potassium. With the thiazide, hypokalemia may be intensified, which matters in patients with cardiac disease or receiving repeated or infused doses.
What this interaction means in plain words
Epinephrine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Beta-2 mediated potassium shift into cells adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium when epinephrine is given repeatedly or by infusion, and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Epinephrine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine promotes cellular potassium uptake via beta-2 receptors and may lower serum potassium. With the thiazide, hypokalemia may be intensified, which matters in patients with cardiac disease or receiving repeated or infused doses.
How serious is the interaction between Epinephrine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when epinephrine is given repeatedly or by infusion, and correct hypokalemia.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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