Drug interactions
Epinephrine + Insulin degludec / insulin aspart
Severity: Moderate
Epinephrine and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine raises blood glucose and can counteract insulin, so glycemic control may worsen. Epinephrine may also mask the warning signs of hypoglycemia once its effect wears off.
What this interaction means in plain words
Epinephrine and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through increased hepatic glycogenolysis and gluconeogenesis and reduced insulin secretion.
What to do
Monitor blood glucose more frequently during and after epinephrine use and adjust insulin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Epinephrine and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine raises blood glucose and can counteract insulin, so glycemic control may worsen. Epinephrine may also mask the warning signs of hypoglycemia once its effect wears off.
How serious is the interaction between Epinephrine and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during and after epinephrine use and adjust insulin as needed.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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