Drug interactions
Epinephrine + Iobenguane i
Severity: Major
Epinephrine and Iobenguane i: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine may compete with iobenguane for norepinephrine transporter uptake into adrenergic tissue. This can reduce tracer uptake and produce false-negative scans.
What this interaction means in plain words
Epinephrine and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive inhibition of norepinephrine transporter uptake of iobenguane.
What to do
Where clinically feasible, withhold interfering drugs for several half-lives before imaging, as in iobenguane labeling. Reschedule imaging if the drug cannot be stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Iobenguane i?
MediHelp rates the interaction as major. Epinephrine and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Epinephrine may compete with iobenguane for norepinephrine transporter uptake into adrenergic tissue. This can reduce tracer uptake and produce false-negative scans.
How serious is the interaction between Epinephrine and Iobenguane i?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically feasible, withhold interfering drugs for several half-lives before imaging, as in iobenguane labeling. Reschedule imaging if the drug cannot be stopped.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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