Drug interactions
Epinephrine + Levosalbutamol
Severity: Moderate
Epinephrine and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine and levosalbutamol are both adrenergic agonists. Together they may cause excessive tachycardia, arrhythmias, hypertension, tremor and a fall in serum potassium.
What this interaction means in plain words
Epinephrine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Levosalbutamol belongs to Respiratory.
Why it happens
Additive adrenergic receptor stimulation, including beta-2 mediated intracellular potassium shift.
What to do
Monitor heart rate, blood pressure and ECG, and check potassium when high doses are used. In emergencies such as anaphylaxis, epinephrine should still be given when indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epinephrine and Levosalbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levosalbutamol
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Levosalbutamol?
MediHelp rates the interaction as moderate. Epinephrine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine and levosalbutamol are both adrenergic agonists. Together they may cause excessive tachycardia, arrhythmias, hypertension, tremor and a fall in serum potassium.
How serious is the interaction between Epinephrine and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and check potassium when high doses are used. In emergencies such as anaphylaxis, epinephrine should still be given when indicated.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
