Drug interactions
Epinephrine + Methoxyflurane
Severity: Major
Epinephrine and Methoxyflurane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Halogenated anesthetics like methoxyflurane sensitize the myocardium to catecholamines. Epinephrine may then provoke ventricular arrhythmias and hypertension.
What this interaction means in plain words
Epinephrine and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Myocardial sensitization to catecholamines by the anesthetic, increasing arrhythmogenicity.
What to do
Avoid systemic epinephrine during methoxyflurane anesthesia where possible, or use minimal doses with continuous ECG monitoring. Have antiarrhythmic treatment available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Methoxyflurane?
MediHelp rates the interaction as major. Epinephrine and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Halogenated anesthetics like methoxyflurane sensitize the myocardium to catecholamines. Epinephrine may then provoke ventricular arrhythmias and hypertension.
How serious is the interaction between Epinephrine and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic epinephrine during methoxyflurane anesthesia where possible, or use minimal doses with continuous ECG monitoring. Have antiarrhythmic treatment available.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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