Drug interactions
Epinephrine + Olodaterol inhaled
Severity: Moderate
Epinephrine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olodaterol is a long-acting beta-2 agonist, and adding epinephrine may enhance cardiovascular effects such as tachycardia, palpitations, arrhythmia and blood pressure rise. Hypokalemia may also be additive.
What this interaction means in plain words
Epinephrine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic stimulation.
What to do
Monitor heart rate, blood pressure and ECG when epinephrine is given to patients on olodaterol. Do not withhold epinephrine in anaphylaxis, but watch for arrhythmias and low potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Epinephrine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olodaterol is a long-acting beta-2 agonist, and adding epinephrine may enhance cardiovascular effects such as tachycardia, palpitations, arrhythmia and blood pressure rise. Hypokalemia may also be additive.
How serious is the interaction between Epinephrine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when epinephrine is given to patients on olodaterol. Do not withhold epinephrine in anaphylaxis, but watch for arrhythmias and low potassium.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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