Drug interactions
Epinephrine + Promazine
Severity: Moderate
Epinephrine and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine, a phenothiazine, has alpha-blocking properties that can reverse the pressor effect of epinephrine and cause hypotension. It can also prolong the QT interval, adding to arrhythmic risk.
What this interaction means in plain words
Epinephrine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic blockade by the phenothiazine unmasks epinephrine's beta-mediated vasodilation, with additive QT effects.
What to do
Avoid using epinephrine to treat phenothiazine-induced hypotension and use norepinephrine or phenylephrine instead. Monitor blood pressure and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Promazine?
MediHelp rates the interaction as moderate. Epinephrine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine, a phenothiazine, has alpha-blocking properties that can reverse the pressor effect of epinephrine and cause hypotension. It can also prolong the QT interval, adding to arrhythmic risk.
How serious is the interaction between Epinephrine and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using epinephrine to treat phenothiazine-induced hypotension and use norepinephrine or phenylephrine instead. Monitor blood pressure and ECG.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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