Drug interactions
Epinephrine + Selegiline transdermal
Severity: Major
Epinephrine and Selegiline transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressant-dose transdermal selegiline inhibits MAO nonselectively and may potentiate the pressor effects of sympathomimetics. Systemic epinephrine could cause hypertensive reactions, though the effect is less than for indirect agents.
What this interaction means in plain words
Epinephrine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition reduces catecholamine metabolism, enhancing sympathomimetic pressor effects.
What to do
Avoid nonessential systemic epinephrine; for anaphylaxis, give it as indicated with close blood pressure and ECG monitoring. Local anesthetic with epinephrine should use minimal doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Selegiline transdermal?
MediHelp rates the interaction as major. Epinephrine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antidepressant-dose transdermal selegiline inhibits MAO nonselectively and may potentiate the pressor effects of sympathomimetics. Systemic epinephrine could cause hypertensive reactions, though the effect is less than for indirect agents.
How serious is the interaction between Epinephrine and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonessential systemic epinephrine; for anaphylaxis, give it as indicated with close blood pressure and ECG monitoring. Local anesthetic with epinephrine should use minimal doses.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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