Drug interactions
Epinephrine + Thiothixene
Severity: Moderate
Epinephrine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with alpha-adrenergic blocking activity can reverse the pressor effect of epinephrine, leaving beta-mediated vasodilation unopposed and causing hypotension and reflex tachycardia. This is relevant when epinephrine is used to treat shock or anaphylaxis in a patient taking thiothixene.
What this interaction means in plain words
Epinephrine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-1 receptor blockade by thiothixene unmasks the beta-2 vasodilatory action of epinephrine (epinephrine reversal).
What to do
Monitor blood pressure closely if epinephrine is required and be prepared to use a pure alpha agonist such as norepinephrine or phenylephrine if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Thiothixene?
MediHelp rates the interaction as moderate. Epinephrine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics with alpha-adrenergic blocking activity can reverse the pressor effect of epinephrine, leaving beta-mediated vasodilation unopposed and causing hypotension and reflex tachycardia. This is relevant when epinephrine is used to treat shock or anaphylaxis in a patient taking thiothixene.
How serious is the interaction between Epinephrine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely if epinephrine is required and be prepared to use a pure alpha agonist such as norepinephrine or phenylephrine if hypotension persists.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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