Drug interactions
Epinephrine + Trifluoperazine
Severity: Moderate
Epinephrine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has alpha-blocking activity that can reverse epinephrine's pressor effect and produce hypotension. It can also prolong the QT interval, adding to arrhythmic risk.
What this interaction means in plain words
Epinephrine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic blockade unmasks epinephrine's beta-mediated vasodilation, with additive QT effects.
What to do
If hypotension occurs in a patient on phenothiazines, use norepinephrine or phenylephrine rather than epinephrine, except in anaphylaxis. Monitor blood pressure and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Trifluoperazine?
MediHelp rates the interaction as moderate. Epinephrine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has alpha-blocking activity that can reverse epinephrine's pressor effect and produce hypotension. It can also prolong the QT interval, adding to arrhythmic risk.
How serious is the interaction between Epinephrine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If hypotension occurs in a patient on phenothiazines, use norepinephrine or phenylephrine rather than epinephrine, except in anaphylaxis. Monitor blood pressure and ECG.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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