Drug interactions
Epinephrine + Yohimbine
Severity: Moderate
Epinephrine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine blocks presynaptic alpha-2 receptors and increases norepinephrine release, raising blood pressure and heart rate. Together with epinephrine, hypertension, tachycardia, anxiety and arrhythmias may be amplified.
What this interaction means in plain words
Epinephrine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects from alpha-2 antagonism by yohimbine and direct adrenergic agonism by epinephrine.
What to do
Monitor blood pressure and heart rate when epinephrine is given and avoid unnecessary epinephrine in patients using yohimbine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Yohimbine?
MediHelp rates the interaction as moderate. Epinephrine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine blocks presynaptic alpha-2 receptors and increases norepinephrine release, raising blood pressure and heart rate. Together with epinephrine, hypertension, tachycardia, anxiety and arrhythmias may be amplified.
How serious is the interaction between Epinephrine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is given and avoid unnecessary epinephrine in patients using yohimbine.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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